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While this methylation reaction was historically considered a relatively minor metabolic pathway for nicotinamide clearance, research over the past decade has revealed that NNMT plays a surprisingly important and previously underappreciated role in cellular energy metabolism, NAD+ homeostasis, adipocyte biology, and whole-body metabolic regulation

The bottom line: if you're formulating GHK-Cu for cosmetic research and skipping the calculator step, you're not saving time

As of writing, studies in laboratory animals have not identified significant safety concerns [3, 4]

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Journal of US Pharmacist

Because it carries oleic acid (C18) and palmitic acid (C16), this ingredient may not be fungal acne safe