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In overweight adults, one study showed ~15% weight loss over 68 weeks in the STEP 1 trial

Now that the supply has stabilized, the FDA has removed GLP-1 therapies from the national shortage list, suggesting these medications should be easier to access

Signaling components of redox active endosomes: the redoxosomes

In 2024, Wegovy was also approved to reduce the risk of heart attack, stroke, or cardiovascular death in obese or overweight adults with cardiovascular disease

These include liraglutide (Saxenda) and semaglutide (Wegovy), representing an expansion beyond their original diabetes indication and highlighting the broader metabolic impact of GLP-1 pathway activation

Analogs based on the human GLP-1 structure have also been developed [10,11]