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No significant change was observed in the transient response in the presence of a purinergic antagonist, whilst the plateau phase of AngII responses was largely attenuated following pre-treatment with PPADS (Supplementary Figure 5e, g, h)

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It works by causing a release of norepinephrine

Water activity and pH also work synergistically to provide microbial protection at values higher than those required when only one control factor is considered (4)

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The stratum corneum presents an equally significant barrier for topical routes