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As an endoglycosidase, heparanase cleaves heparan sulfate chains, thereby releasing growth factors and other bioactive molecules anchored to the extracellular matrix (ECM)
However, because of a lower ratio of kidney/liver -lyase activity in human than rodents, kidney selectivity remains to be confirmed
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CJC-1295 is a tetrasubstituted form of sermorelin that also mimics the function of the growth hormone-releasing hormone (GHRH) but possesses enhanced stability
This is in part established by glutathione, a redox-active metabolite present in reduced (GSH) and oxidized (GSSG) forms