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In some embodiments, local otic delivery of the auris formulations or compositions described herein allows for controlled release of active agents to auris structures and overcomes the drawbacks associated with systemic administration (e.g., low bioavailability of the drug in the endolymph or perilymph, variability in concentration of the drug in the external, middle and/or internal ear)

Applied once daily to the scalp, minoxidil helps to prolong the hair growth cycle

(Source for TB-500/T4 distribution, Globular Actin mechanism, half-life, and general PK)

Proceedings of the National Academy of Sciences of the United States of America

Identity fields were photographed at each time point, and the healed areas were measured with ImageJ software (National Institutes of Health, Bethesda, MD, United States)

Rotate injection sites systematically (e.g