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10.1016/j.amjmed.2009.03.014

Tolessa T, Gutniak M, Holst JJ, Efendic S, Hellstrm PM

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MOTS-C works through the AMPK pathway and mitochondrial signaling

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The viral hijack of human ACE2 receptor disrupts RAAS activation, upregulates NF-B pathway, triggers cytokine storm, hypertension, cell proliferation, inflammation, and fibrosis, where all elicit detrimental effects on every bodily organ during SARS-CoV-2 infection 635