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However, Huberman recommends cycling this supplement 8 weeks on and two weeks off to avoid any potential toxicity, which has been reported in individuals who took this supplement at extremely high doses

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Furthermore, vagus nerve-dependent signaling has been shown to mediate peripheral microbial effects on GDNF expression, with stimulation of enteroendocrine cells and immune receptors (TLR2, TLR4) activating downstream PI3K/Akt and MAPK pathways that promote neurotrophic factor production in the CNS

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