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For example, individuals with loss-of-function mutations of the DPP1 gene develop prepubertal aggressive periodontitis, Papillon-Lefvre syndrome (PLS) ( In this review, we provide an overview of DPP1, its functional biochemical properties, the consequences of its inactivation and deficiency, and NSP pathophysiology in a variety of disorders

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When administered, Sermorelin mimics GHRH, stimulating pulsatile growth hormone secretion , which is crucial for downstream production of insulin-like growth factor 1 (IGF-1) in the liver

PMCID: PMC8875106.