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While B12 is undoubtedly essential for these functions, its important to approach B12 IM injections with realistic expectations, as individual responses can vary

Maeng S, Zarate CA Jr, Du J, et al

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Consequently, the GSH deprotonation step was considered non-rate-determining and thermodynamically favoured, leading us to use the GSH-thiolate as the starting point to compute the reaction mechanism for the conversion of flav-3-on-4-ol ( 7 ) into cyanidin ( 8-B4 ) in the wild-type enzyme and the C13S variant (Extended Data Fig

The reason for this discrepancy is not known but could be related to differences in patient cohorts

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