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People often use fiber supplements to treat constipation
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Once enrolled in the DAPA-HF trial, adult patients were not required to discontinue therapy if eGFR fell below 30 mL/min/1.73 m2 or if dialysis was initiated [see Dosage and Administration (2.3) and Clinical Studies (14.4,14.5)]
[DOI] [PubMed] [Google Scholar] 53.Chiarella S.E., Barnes P.J
Randomized controlled trials, observational studies, meta-analyses, and pharmacovigilance reports evaluating GI adverse effects of GLP-1based therapies were included
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