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The precautionary approach recommended by the FDA reflects an abundance of caution rather than documented contraceptive failures

There are documented case reports of extreme appetite suppression and psychiatric complications requiring GLP-1 discontinuation in people with restrictive eating patterns ( Leziak et al., J Psychiatric Research, 2026 )

If TSH is normal, the fatigue is likely tirzepatide-related and typically improves as your body adjusts to the current dose

J Clin Endocrinol Metab 2019

However, there is a chance that patients will develop iron deficiency

Therefore, as an autoimmune disease, GD can cause systemic immune activation and high levels of inflammatory factors in the circulation, leading to the activation of the HPA axis and hypersecretion of related hormones