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Store at 20 to 25 C and protect from freezing

For silencing FOXO4, specific small interfering RNA (siRNA) was employed, with a negative control siRNA, and transfection was conducted using Lipofectamine 3000 [2]

By selectively inhibiting NNMT an enzyme central to energy regulation and fat metabolism this compound has demonstrated, in preclinical studies, the capacity to elevate intracellular NAD and SAM levels, suppress lipid accumulation in adipocytes, and reduce white adipose tissue mass in diet-induced obese mouse models

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Journal of Physiology, Paris, 97 (23), 221226