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This approach potentially enables more efficient trial design through improved patient selection and outcome prediction, potentially reducing sample size requirements and trial duration

The slow dose escalation exists specifically to minimise side effects while the body adjusts

(iii) left atrial enlargement defined by local laboratory

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As both of these studies were performed in male Wistar rats, future studies should examine the effects of GLP-1 receptor antagonism in female subjects

All the experiments were in accordance with directives of Principles of Laboratory Animal Care (NIH publication No