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Some patients may remain on the same dose longer because of side effects, medical history, treatment response or provider judgment

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The Ca axis is associated with activation of phospholipase C or GMP-specific phosphodiesterase, followed by the release of intracellular Ca into the cytosol to activate downstream signaling proteins consisting of CREB and NFAT transcription factors mainly to regulate migration [90, 92]

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As scientists continue to search for a cure , some are taking matters into their own hands