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Both the application of antibiotic stewardship principles and timely considerations through the regulatory pathways are needed to release the next generation of antibiotics that are suitable for the fight against superbugs

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In murine models, the activation of GLP-1 receptors within the VTA has been shown to attenuate the synaptic strength of the VTA-NAcc pathway,154 although GLP-1 receptor expression in VTA neurons is relatively sparse.155 Rat studies indicate that GLP-1 receptor activation in the VTA can enhance dopaminergic neuronal activity via presynaptic mechanisms.156 Despite preclinical evidence and limited clinical trials, the precise influence of GLP-1 receptor stimulation on the effects of abused drugs and alcohol remains unclear

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[DOI] [PubMed] [Google Scholar] 50.He W, Li J