tirzepatide nejm vs Semaglutide for Obesity – NEJM, May 2025 Relevant to endocrinology, internal medicine, cardiology, obesity medicine • Tirzepatide: −20.2% weight loss at 72 wks • Semaglutide: −13.7% • Greater waist reduction Tirzepatide as Compared with Semaglutide

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22 Impurity Risks: Litigation filings have highlighted that bulk synthetic semaglutide often contains higher levels of impurities, including formaldehyde adducts and dimers, compared to pharmaceutical-grade equivalents

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