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However, despite widespread use of ivermectin over the past few decades for several indications, reports of resistance to date have been limited and contentious (Crump et al

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Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

However, without concrete evidence, the theory was largely forgottenuntil now

Int J Mol Med (2018) 41(5):297785

Besides, numerous unexplored bacteria are possible sources of various antibiotics