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Perrin, J

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O., French, R., Novack, M

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This issue was partially addressed in the PARAGON-HF trial.44 The investigators found not only that hs-TnT was reduced by sacubitril/valsartan therapy compared with valsartan, but also that patients with a decrease in hs-TnT from randomisation to 16 weeks to a value to at or below the median value of 17 ng/l subsequently had lower risk of the composite outcome compared with those who had persistently elevated hs-TnT values.44 Further research will be required to determine whether therapies targeting the mechanism of hs-cTn elevation can improve symptom burden and clinical outcomes in the HFpEF population