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Acknowledgments This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors

In preclinical studies, compounds such as VX-765 and pralnacasan have demonstrated efficacy in inhibiting caspase-1 activation and protecting against inflammatory diseases

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Then, activity-based probes can be used to explore the changes in reactivity of active site-localised nucleophiles (Figure 1C)

The osteoprotective effect of silymarin was comparable to that of oestrogenic isoflavones

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