51 Downstream of RAS The best characterized downstream pathways stimulated by active RAS are mitogen-activated protein (MAP) kinase (RAF/MEK/ERK/p90RSK) and phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR, which promote cell multiplication, survival, and metastasis (scheme in Fig
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The filing coincides with increased scrutiny over industry influence on public health policy