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These hepatokines circulate and exert a Distant crosstalk effect, influencing processes like glucose uptake, fatty acid breakdown, liver glucose production, inflammation, and various other functions in peripheral tissues

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[CrossRef] [PubMed] 59

Clinically, Alzheimers disease patients show elevated pro-inflammatory gut bacteria, with direct correlations between gut dysbiosis severity and brain inflammation markers (Liu et al., 2020