Commenting on the MHRA approval, Rani Khatib, consultant pharmacist in cardiology and cardiovascular research at Leeds Teaching Hospitals NHS Trust, said: The data for GLP-1 agonists being of benefit for reducing cardiovascular outcomes and also impacting positively on kidney function [is] growing. However, he warned that supply of semaglutide was a big challenge that needed addressing not just nationally but globally, with off-label use and private prescribing putting huge pressure on the system
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Microdosing semaglutide means using weekly doses between 0.05 mg and 0.25 mg, below the FDA titration start point, to keep partial appetite suppression while cutting side effects and cost
most participants (98.4%) were initiated on the 3 mg dose, and three participants (1.6%) received the 7 mg dose at baseline
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