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Keller J, Trautmann ME, Haber H, San Tham L, Hunt T, Mace K, Linnebjerg H

In 2,339 participants at the 12mg dose, the safety profile was consistent with TRIUMPH-4 and GLP-1 class expectations with one important improvement: discontinuation due to side effects dropped to 11.3% , compared to 18.2% in TRIUMPH-4's osteoarthritis population

[12] [21] Importantly, the absolute amount of muscle lost correlates strongly with total weight losspatients losing more weight inevitably lose more lean mass in absolute terms, but the proportion remains relatively stable

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