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The Gene Expression Paradox refers to the observation that BPC-157 is cleared from systemic circulation in approximately 15 minutes (mean elimination half-life in rats), yet its reparative effects persist for weeks

PlGF has been reported to enhance pathological angiogenesis by initiating a cross-talk between VEGFR-1 and VEGFR-2 [130], while others have demonstrated anti-angiogenic properties of PlGF [131]

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