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Precautions Do not use in patients with a known allergy or previous hypersensitivity reaction to any ingredients, active inflammation of a superficial vein, significant dysfunction of vein valves or deep vein insufficiency, large superficial veins that connect to deeper veins, a history of migratory phlebitis, or an active skin and soft tissue infection, such as cellulitis

Staying hydrated and avoiding rapid position changes helps manage this effect

By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, which thus remains available for recycling to NAD+ via the salvage pathway

rather all three should be seen as partners in success