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Beyond CPPs, other functional peptides have also been exploited for PNA delivery

Hagen, TM, Liu J, et al

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2

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The more constitutively expressed PTGS1 and the more readily inducible PTGS2 (by cytokines and growth factors particularly) are commonly referred to as cyclooxygenase-1 (COX-1) and -2 (COX-2), respectively [78]

This synergistic combination pairs a classic GHRH analog with a highly selective ghrelin receptor agonist to allow for sophisticated in vitro and in vivo modeling