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Mechanism 2: Pheomelanin Shift Glutathione reacts with DOPAquinone directly, diverting it toward pheomelanin synthesis rather than eumelanin

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Others notice tingling or numbness in their hands and feet as nerve function becomes affected

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Studies have shown that downregulating the PI3K/AKT/mTOR pathway can increase cellular sensitivity to ferroptosis by downregulating the expression of downstream factors such as GPX4, SREBP1, and SLC7A11 ( 2+ , ultimately alleviating SLI in mice (Zhou et al., 2024)