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However, the addition of NAD + and CoA did not restore functional lipoylation within 30 min, suggesting that while the intrinsic capacity of the OGDHc may resolve lipoyl adducts over time, ABHD11 restores functional lipoylation more rapidly

Barrea L, Altieri B, Polese B, De Conno B, Muscogiuri G, Colao A, Savastano S

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Additionally, more compounds make it harder to isolate which one is responsible for any observed benefit (or harm)

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