However, tumor tissues often exhibit an altered iron metabolism characterized by increased iron uptake and retention, a phenomenon known as iron addiction. Many malignancies, such as breast cancer, prostate cancer, and hepatocellular carcinoma, achieve this by upregulating TFR1 to enhance iron uptake while downregulating FPN to reduce iron export, ensuring a continuous supply of iron to support rapid tumor proliferation and metabolic reprogramming ( Interestingly, the relationship between systemic ID and tumor iron levels is not uniform across all cancers
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Furthermore, mice that survived the primary pancreatic tumor after cps treatment showed strong immune protection against the recurrence of pancreatic cancer
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Semaglutide alleviates gut microbiota dysbiosis induced by a high-fat diet
However, the researchers found that intracellular lipoxygenase levels were significantly increased
