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When it fails, the consequences can be severe

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51,55 These data across various models consistently indicate that the final step of ferroptosis signaling, i.e., LPO, needs to be increased by 10- to 50-fold over constitutive levels to be biologically relevant

These observed benefits do not seem to correlate with the glucose-lowering effect, and the underlying mechanism is being intensively investigated

Some variants may have increased positive or negative charges, or blocked charges, which can affect their purification, biological activity, and safety