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Patients carrying certain variants of the GLP1R rs6923761 polymorphism, for example, may experience more pronounced digestive changes because their receptors have different sensitivity to the medication
Potential candidates for off-label use: Clinicians may consider GLP-1 therapy for women with PCOS who meet the following criteria: Overweight or obesity (particularly BMI 30 kg/m) with PCOS Insulin resistance or impaired glucose tolerance Inadequate response to lifestyle modification and other treatments No contraindications to GLP-1 therapy Not planning pregnancy in the immediate future Contraindications and precautions: GLP-1 receptor agonists are contraindicated in pregnancy and breastfeeding
Tirzepatide is slightly different
BPC-157 Concerns FDA states that BPC-157 may present immunogenicity risks for certain routes because of aggregation and peptide-related impurities
They can provide guidance, answer questions, and adjust prescriptions as needed
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