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Calprotectin is an FDA-cleared inflammatory biomarker capable of helping differentiate IBS from inflammatory bowel disease, and a significantly elevated result should prompt referral and conventional workup including colonoscopy to rule out Crohn's or ulcerative colitis not a permeability-repair protocol

Second: dual-mechanism molecules that pair GLP-1 receptor agonism with PDE4 inhibition in a single agent, or that pair GLP-1 agonism with other intracellular signal-stabilization machinery

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Carnitine Deficiency People who follow a vegetarian or vegan diet are at higher risk of carnitine deficiency because it is primarily found in animal products