If constipation persists after 12 weeks of diet and exercise optimization, then laxative support or dose reassessment becomes appropriate, supported by conversation with your healthcare team about your individual response pattern
Additionally, a randomized trial showed a benefit in disease-free survival in breast cancer patients receiving presurgical peritumoral injection of lidocaine, which is also a VGSC inhibitor (331)
Reassess your diet and exercise routine, adjust your goals, and focus on the other benefits exercise is bringing you, like increased energy or confidence
Severe caloric restriction sometimes impairs concentration and mental clarity, likely due to low glucose availability and potential micronutrient deficiencies
Depending on the patient, lab testing may help evaluate hormone patterns, thyroid function, blood sugar regulation, nutrient deficiencies, inflammatory markers, and other indicators that may impact weight-loss success
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