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Previous studies showed that NF-B (p65) knockdown could significantly reduce the expression of MMPs and inflammatory factors in chondrocytes that were treated with IL-1 and TNF- 51

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Nature, 586 (7829), 434439

However, researchers also observed less-documented complaints, including fatigue, temperature sensitivity (chills or hot flashes), and menstrual changes

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PMID: 24694282 Martens ME, Lee CP (1984): Reye's syndrome: salicylates and mitochondrial functions