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The isolated TIF was snap-frozen in liquid nitrogen and stored at 80 C before analysis

Understanding each option helps inform discussions with healthcare providers

Metformin, a first-line biguanide medication, works by reducing liver glucose production and improving insulin sensitivity

Split dosing (dividing the daily amount into two injections, morning and evening) maintains more consistent tissue levels throughout the day

10.3390/jcm10112382 20 BuczyskaA.SidorkiewiczI.RoguckiM.SiewkoK.AdamskaA.KociuszkoM.et al (2021a)

Recurrence of pain requiring therapy is common (in 30% to 60% of patients) within 6 to 12 months after treatment (19)