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Samples were separated using a Kinetex 2.6 m XB-C18 100 , 100 2.1 mm LC Column (Phenomenex) with a constant flow rate of 250 l/min following a flow gradient starting at 70% Mobile Phase B (ACN + 0.5% Acetic acid, AA) then going up to 99% for 5 min before re-equilibration at 70% for 5 min

TMLHE mutations are surprisingly common Two recent studies have found that the prevalence of TMLHE mutations in human populations may range from about 1 in 350 to about 1 in 900

Bax, Bax, Bcl-2, associated X protein

After four weeks, the dose increases to 0.5mg weekly

(A) Risk of bias summary and (B) risk of bias graph according to the Cochrane Risk of Bias assessment tool, visualized using the Robvis program

Trennmittel: Xanthan