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PMID: 30796433 2 Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders

The science of neuroendocrinology was advanced conceptually 50 years ago by the independent discoveries of Schally, Leeman and Reichlin, demonstrating that the gut peptides thyrotropin-releasing hormone (TRH) ( The BBB does not impair access of sex steroids to the CNS to the same extent as gut peptides

doi: 10.3390/ijms23136996 194 SergienkoNMTrewinAJKiriazisHRaaijmakersAJADonnerDGGarsideVCet al

The risks are substantial and currently undefined

Or it could be that the drugs wont work well enough for these conditions

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