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Despite the inherent resistance of EMS tissue to ferroptosis, studies have shown that Erastin can still effectively induce ferroptosis in EMS lesions, leading to tissue atrophy and cell death

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(PubMed) Vieira AR, Vingeliene S, Chan DS, et al

We then performed sequence alignment of PDS5B 1308-1394 against the equivalent region in several PDS5B orthologs to identify conserved lysine and arginine residues that could be involved in interactions with the negatively charged phosphodiester backbone of DNA

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