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We demonstrated therapeutic protection of photoreceptor structure and function in a chemically-induced rat model of RP (48% increase in photopic b-wave amplitude), as well as some limited protection in an aggressive genetic mouse model ( rd10 ) of retinal degeneration (~ 31% increase in photopic b-wave amplitude) with once daily application

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Given its potent redox capabilities, and its high intracellular concentration and widespread distribution, its role as a potent defense mechanism against oxidative and electrophilic stress is well-established

The function of exosomes in cell-to-cell communication, protein or RNA transport, immune response regulation, antigen presentation, and non-classical secretion of proteins is reviewed by Simpson et al

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10.1016/j.freeradbiomed.2017.01.004 [DOI] [PubMed] [Google Scholar] Gamcsik M.P., Kasibhatla M.S., Teeter S.D., and Colvin O.M