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Within the H-site, the substrate analogue ( 12 ) interacts through hydrogen bonds to N108 and the backbone of V12, a interaction with F112, water bridges to R16 and Y175, and hydrophobic interactions with V12 and V115 (Fig

10.1038/nsmb.2608 93 LinK.WeiW.ChenS.GongY.WangX.WangM.et al (2025)

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Metabolic associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), and metabolic-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH), are conditions linked to obesity and insulin resistance

This type of fat, known as visceral fat, wraps around organs and increases the risk of type 2 diabetes, fatty liver, and cardiovascular disease

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