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Provides Cardiovascular Benefits (Anti-inflammatory) Clinical trials (e.g., SUSTAIN-6, SELECT) have shown semaglutide reduces the risk of major adverse cardiovascular events (heart attack, stroke, CV death) in people with type 2 diabetes and high cardiovascular risk

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STEP 1 and OASIS 4 were separate trials in different populations, so this is an indirect comparison rather than a head-to-head study but the overall efficacy signal is consistent across both

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Both semaglutide and tirzepatide share common side effects like constipation, fatigue, and nausea