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The amount of riboflavin is lower in PD patients compared to healthy and disease controls, suggesting that taking riboflavin supplements may be beneficial (Coimbra and Junqueira, 1988) and daily doses of riboflavin for 6 months showed improved motor capacity of PD patients in 3 months (Coimbra and Junqueira, Among the Supplements Creatine Shows the Most Promise as a Neuroprotective Agent Coenzyme Q10 (CoQ10), also known as ubiquinone, is a promising agent for neuroprotection in PD and other neurodegenerative diseases because of its role in the mitochondrial electron transport chain (METC) and as an antioxidant (Beal and Shults, 2004), suppressing intra-mitochondrial and intra-nuclear biosynthesis of 8-OH-2dG, inhibiting translocation of caspase-3, attenuating -synuclein expression, and blocking intra-mitochondrial accumulation of metal ions (Ebadi et al., Animal studies have shown that rotenone-induced parkinsonism reduced CoQ10 concentrations in plasma and the striatum with a corresponding decrease in striatal levels of DA, mitochondrial complex I activity and ATP levels, as well as significant increase in B-cell lymphoma 2 (Bcl-2) expression (Abdin and Hamouda, 1999)
Its one of those things that can sneak up on you until one day you look in the mirror and think, Who the hell is that? Its a sign that our biological systems are slowly but surely breaking down thanks to the wear and tear of life (environmental stressors and oxidative damage)
Glutathione supports immune health and overall resilience
Robinson, D.S., Ying, S., Bentley, A.M., Meng, Q., North, J., Durham, S.R., Kay, A.B., Hamid, Q., Relationship among numbers of bronchjoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacoline responsiveness in atopic asthma, J
Tryptophan metabolism appears to be differentially altered in ME/CFS and FM, relative to healthy controls, potentially contributing to the symptoms of each condition
