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Ascorbic acid modulates the hypothalamic-pituitary-adrenal (HPA) axis ( Figure 4 ) by directly braking cortisol secretion (102)

As a primary therapeutic option for adolescent PCOS, metformin, whether used either as a standalone therapy or in conjunction with oral contraceptives, can effectively reduce androgen levels, alleviate hyperandrogenism symptoms, restore regular menstrual cycles, ameliorate IR, and reduce the likelihood of long-term cardiovascular complications

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doi: 10.3389/fphar.2021.772510