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10.1161/CIRCRESAHA.116.305372 Circ Res

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On day 14, there is still an infiltration of inflammatory cells in controls, presented moderate edema which disappears not before the day 28 (Figure 9), sustainable, but delayed discrete increase of vascularity with the discrete proliferation of fibroblast and production of reticulin and collagen fibers making loose connective tissue with mesh-like fibers, areolar tissue

Further rodent studies emphasized the gut microbiotas integral role in orchestrating systemic immune responses, indicating that a balanced microbiome conditions the lung milieu for defense by modulating interferon (IFN) signaling pathways

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