Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone
"Increases in GLP-1RA dispensing were greatest for females, highlighting the importance of educating patients and prescribers on sex-specific safety risks [eg, concerns during pregnancy]," the team noted
No one really knows how these drugs should be used before pregnancyor during it for that matter
IGF-1R Receptor Binding and Downstream Signalling Both IGF-1 and des-(1-3)IGF-1 bind only to the type 1 IGF receptor in L6 myoblasts, rat vascular smooth-muscle cells, and human lung fibroblasts, with binding potencies in the order des-(1-3)IGF-1 greater than IGF-1 a difference attributed to the lower affinity of des-(1-3)IGF-1 for the competing IGFBP rather than superior intrinsic receptor affinity
(Mechanism and aging context.) Sassolas G, et al
B12 addresses the tolerability problem