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In any scientific study, the dose is your primary independent variable

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Neuro-bone tissue engineering: multiple potential translational strategies between nerve and bone

The destruction of the mitochondrial electron transport chain (ETC) leads to an increase in ROS production, which triggers matrix metalloproteinases (MMP) induction, ultimately disrupting tight junctions and increasing BBB permeability

Most benefits appear in patients with insulin resistance or prediabetes, where normalizing glucose dynamics has secondary weight-management effects

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