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(PubMed) Lombard KA, Olson AL, Nelson SE, Rebouche CJ
Ibuprofen at a moderate amount (100 mg/kg/day) affected more proteins and pathways in mice liver than expected, including glycolysis, protein degradation, fatty acid metabolism and antioxidant system
There are a couple of other scenarios in which acetaminophen is more likely to cause liver damage: Alcohol Use Disorder: Normally, alcohol is metabolized using the alcohol dehydrogenase enzymes, but in cases of chronic overconsumption or binge drinking, the CYP2E1 enzyme is upregulated to metabolize the extra alcohol
Romaldini JH, Biancalana MM, Figueiredo DI, Farah CS, Mathias PC