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In the STEP 1 trial (published in the New England Journal of Medicine), participants using Wegovy lost an average of 14.9% of their body weight over 68 weeks approximately 35 lbs from a starting weight of 232 lbs

This study provides insight into how differential dynamics of peptideligand engagement with the GLP-1R TMD can promote differences in G protein-mediated signalling, improving molecular understanding of mechanisms that contribute to ligand-dependent differential efficacy at the GLP-1R

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They refer to the sagging skin or loss of volume in the face or buttocks that can occur with rapid weight loss