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Kidneys are especially prone to oxidative stress due to their high energy needs and robust blood supply

on the other hand, excessive ROS can damage host mitochondria, impair immune function, and promote parasite persistence

Small molecule drugs may offer the possibility of oral administration, which is more convenient and acceptable for patients

Although PPIs are used worldwide to treat acid-related disorders, their excessive consumption can lead to disruption of microbial community composition in the gut by aiding the colonisation of pathogenic species and increasing the risk of IBD development

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