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As well as causing discomfort through itching which leads to scratching and bleeding it can be very distressing as it is unsightly

The exact cause of IBS remains incompletely understood, but contributing factors include visceral hypersensitivity (increased pain perception in the gut), altered gut motility, changes in the gut microbiome, low-grade inflammation, and psychological factors such as stress and anxiety

Tsang, Y

This guarantees contamination and degradation

All statistical analyses were performed using SAS Enterprise Guide version 7.15 (2017, SAS Institute Inc., Cary, NC, USA), R version 4.0.3 (R Core Team, 2020, and additional R packages (MatchIt, meta)

doi: 10.1186/s11658-023-00501-5 6 LiuJBaoXHuangJChenRTanYZhangZet al